It is the consensus of the medical oncology reference committee to discontinue this protocol as it is not available in Australia and superior alternatives are available.
Treatment schedule summary
Drug |
Dose |
Route |
Day |
Vinflunine |
280 mg/m2 * |
IV infusion |
1 |
* consider starting vinflunine at a dose of 320 mg/m2 in young patients with ECOG 0, normal renal and hepatic function, and no history of prior pelvic radiation therapy. Patients aged 80 and over, consider starting dose at 250 mg/m2.
Frequency: 21 days
Cycles: Continuous until disease progression or unacceptable toxicity
Notes:
-
There is limited efficacy with this protocol; the study showed minimal survival benefit over supportive care, at the expense of increased toxicity.