This document is a quick and concise evidence-based summary to provide additional information, instruction, or guidance to complement a treatment protocol or clinical resource document. 

The compatibility of combinations of doxorubicin, cyclophosphamide, cisplatin and etoposide used in the DT-PACE protocol for multiple myeloma:

  • Cisplatin and etoposide can be combined together in 1000 mL sodium chloride 0.9%.r
  • Doxorubicin and cyclophosphamide can be combined together in 1000 mL sodium chloride 0.9% with expiry of 7 days (at room temperature or refrigerated).r

Alternatively:

  • Cyclophosphamide and etoposide can be combined together in one bag with expiry of 7 days at room temperature.r

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21 Apr 2024