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This document is a quick and concise evidence-based summary to provide additional information, instruction, or guidance to complement a treatment protocol or clinical resource document. 

DGC = Diffuse Gastric Cancer, GC = Gastric Cancer

Testing is indicated in the following situations:

  • person with DGC before the age of 40 years 
  • person with both DGC and lobular breast cancer, with one cancer diagnosed before the age of 50 years 
  • person with GC at any age, who has one or more first/second degree relative/s with gastric cancer at any age, where there is at least one confirmed DGC
  • person with DGC who has one or more first/second degree relative/s with lobular breast cancer, with one case diagnosed before the age of 50 years 
  • person with lobular breast cancer who has one or more first/second degree relative/s with DGC, with one case diagnosed before the age of 50 years. 

Testing could be considered in the following situations:

  • personal history of bilateral lobular breast cancer, with both cancers diagnosed before the age of 50 years
  • person with lobular breast cancer and a family history of lobular breast cancer, with two cases diagnosed before the age of 50 years 
  • person with DGC and cleft lip/palate
  • person with precursor lesions for gastric signet ring cell carcinoma.

The information contained in this document is based on the highest level of available evidence and consensus of the eviQ reference committee regarding their views of currently accepted approaches to care or treatment. Any clinician seeking to apply or consult this document is expected to use independent clinical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. While eviQ endeavours to link to reliable sources that provide accurate information, eviQ and the Cancer Institute NSW do not endorse or accept responsibility for the accuracy, currency, reliability or correctness of the content of linked external information sources. Use is subject to eviQ’s disclaimer available at www.eviQ.org.au

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The currency of this information is guaranteed only up until the date of printing, for any updates please check:

https://www.eviq.org.au/p/3160

29 Mar 2024