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Dominant cancer types in LFS pathogenic variant carriers by age ranger

Age group* Dominant cancer types
Childhood (0-15 years)

Adrenocortical carcinoma

Sarcoma (rhabdomyosarcoma, fibrosarcoma, osteosarcoma, liposarcoma)

Brain tumour (medulloblastoma, astrocytoma, glioblastoma, choroid plexus carcinoma)

Malignant fibrous histiocytoma

Leukaemia

Early adulthood (16-50 years)

Breast cancer

Sarcoma (fibrosarcoma, osteosarcoma, liposarcoma, leiomyosarcoma)

Malignant fibrous histiocytoma

Brain tumour (astrocytoma, glioblastoma)

Leukaemia

Colorectal cancer

Lung cancer

Pancreatic cancer

Prostate cancer

Late adulthood (51-80 years)

Breast cancer

Leiomyosarcoma

Colorectal cancer

Lung cancer

Pancreatic cancer

Prostate cancer

© Curr Opin Oncol 2018

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29 Mar 2024