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Dominant cancer types in LFS pathogenic variant carriers by age ranger

Age group* Dominant cancer types
Childhood (0-17 years)

Adrenocortical carcinoma

Sarcoma (rhabdomyosarcoma, fibrosarcoma, osteosarcoma, liposarcoma)

Brain tumour (medulloblastoma, astrocytoma, glioblastoma, choroid plexus carcinoma)

Malignant fibrous histiocytoma

Leukemia
Early adulthood (16-50 years)

Breast cancer

Sarcoma (fibrosarcoma, osteosarcoma, liposarcoma, leiomyosarcoma)

Malignant fibrous histiocytoma

Brain tumour (astrocytoma, glioblastoma)

Leukemia

Colorectal cancer

Lung cancer

Pancreas cancer

Prostate cancer

Late adulthood (51-80 years)

Breast cancer

Leiomyosarcoma

Colorectal cancer

Lung cancer

Pancreas cancer

Prostate cancer

© Curr Opin Oncol 2018

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https://www.eviq.org.au/p/3501

17 Feb 2020