To see all protocols that comply with the WHO Essential Medicine List 

Dexamethasone is given intravenously prior to the first daratumumab infusion and oral administration may be considered prior to subsequent infusions.

Infusion time Volume 1st hour 2nd hour 3rd hour 4th hour 5th hour 6th hour
First infusion (7 hours) 1000 mL 50 mL/hr 100 mL/hr 150 mL/hr 200 mL/hr (MAX RATE) >
Second infusion (4.3 hours) 500 mL 50 mL/hr 100 mL/hr 150 mL/hr  200 mL/hr (MAX RATE)  
Subsequent infusions (3.5 hours) 500 mL 100 mL/hr 150 mL/hr 200 mL/hr  (MAX RATE)    

Consider incremental escalation of the infusion rate only in the absence of infusion reactions. Dilution volume of 500 mL should only be used if there were no Grade 1 (mild) or greater infusion reactions during the first 3 hours of the first infusion. Otherwise, continue to use a dilution volume of 1000 mL and instructions for the first infusion. Use a modified initial rate for subsequent infusions (i.e. third infusion onwards) only if there were no Grade 1 (mild) or greater infusion reactions during a final infusion rate of ≥100 mL/hr in the first two infusions. Otherwise, continue to use instructions for the second infusion.

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20 Nov 2019