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This fact sheet contains general information about Juvenile Polyposis syndrome (JPS). Each person should see a genetic service for further information and advice.

Key Points

  • JPS is caused by faults (mutations) in the SMAD4 or BMPR1A gene.
  • People with JPS have an increased chance of developing multiple polyps in the bowel and stomach. If these are left untreated, bowel (colorectal) or stomach cancer can develop.
  • People with a faulty SMAD4 gene may also have a condition known as Hereditary Haemorrhagic Telangiectasia (HHT).
  • Family members (including children) can be referred to a genetic service where experts can provide information, advice and support about their chance of developing cancer and the option of genetic testing.

This cancer genetics fact sheet is a guide only and cannot cover every possible situation. The information provided is not intended to replace discussion with a health professional, and should not be interpreted as medical advice. Use of this document is subject to eviQ's disclaimer available at  

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23 Nov 2019