This fact sheet contains general information about BAP1-tumour predisposition syndrome (BAP1-TPDS). Each person should be referred to a genetic service for further information and advice. 

Key Points

  • BAP1-TPDS is caused by faults (mutations) in the BAP1 gene.
  • People with BAP1-TPDS have an increased chance of developing benign (non-cancerous) tumours of the skin called BAP1-inactivated melanocytic tumours (BIMT).
  • People with BAP1-TPDS have an increased chance of developing malignant (cancerous) tumours of the skin (cutaneous melanoma) and eye (uveal melanoma).
  • People with BAP1-TPDS have an increased chance of developing cancer of the lining of the lungs and abdomen (mesothelioma).
  • People with BAP1-TPDS have an increased chance of developing kidney (renal) cancer. 
  • Family members (including teenagers) can be referred to a genetic service where experts can provide information, advice and support about their chance of developing cancer and the option of genetic testing.

This cancer genetics fact sheet is a guide only and cannot cover every possible situation. The information provided is not intended to replace discussion with a health professional, and should not be interpreted as medical advice. While eviQ endeavours to link to reliable sources that provide accurate information, eviQ and the Cancer Institute NSW do not endorse or accept responsibility for the accuracy, currency, reliability or correctness of the content of linked external information sources. Use of this document is subject to eviQ's disclaimer available at www.eviQ.org.au/copyright  

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https://www.eviq.org.au/p/3965

13 Nov 2024