Evidence of mismatch repair deficiency within colorectal carcinoma or polyp.
Colorectal polyposis due to non-adenomatous polyps (e.g. serrated, hamartomatous, juvenile etc).
Colorectal polyposis due to polyps of mixed histology (e.g. significant numbers of both serrated and adenomatous polyps).
Person with isolated, single CHRPE (congenital hypertrophy of the retinal pigment epithelium) after review by an ophthalmologist.
Predictive testing should never be ordered when only an unclassified variant or polymorphism has been identified in a family.