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Referral guidelines for ovarian and endometrial cancer SUPERSEDED

These referral guidelines have been superseded and separated into two referral guidelines; one for ovarian cancer (ID 1905) and the other for endometrial cancer (ID 1953). 

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All of the people who fall into the categories below warrant a referral to a family cancer clinic for genetic counselling and risk management advice. 

The categories highlighted by  ##  have a high probability of being offered germline testing.

Those highlighted by  #  may be offered germline testing following review by a Family Cancer Clinic.

Ovarian
Individual characteristics
Nil as predominately determined by pathology see below
Family history characteristics
High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer with a close relative* with:
    • ovarian cancer, and/or
    • breast cancer		  

#
A blood relative of a known carrier of a germline mutation in a cancer susceptibility gene ##  
Tumour characteristics
High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer age <70 ##   
High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer with personal history of breast cancer ##  
High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer and Jewish ancestry ##  
Endometrial
Individual characteristics 

Endometrial cancer and:
    • macrocephaly and/ or
    • hamartomatous polyps

   #
Endometrial cancer <50   #
Endometrial cancer with personal history of bowel cancer, other gastrointestinal cancer or transitional cell urothelial cancer   #
A blood relative of a known carrier of a germline mutation in a cancer susceptibility gene ##  
Family history characteristics
Invasive epithelial ovarian cancer with a close relative* with:
    • endometrial cancer and/or
    • colorectal cancer		   #

Endometrial cancer and a close relative* with:
    • endometrial cancer; and/or
    • ovarian cancer; and/or
    • colorectal cancer
    • other gastrointestinal cancer or transitional cell urothelial cancer

   #
Tumour characteristics
Endometrial cancer with abnormal mismatch repair protein immunohistochemistry    #

*Relative = 1st or 2nd degree

Note: There is additional information about the criteria for genetic testing of BRCA1 and BRCA2 and Lynch syndrome.

Version 3

Date Summary of changes
14/02/2012 Approved
31/05/2012

Headings Testing Likely and Requires Review deleted as per April 2012 reference committee meeting
15/10/2012 Placed in new format
30/04/2013 Format updated
Tumour characteristics - changed from High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer age <60 to High grade invasive non-mucinous ovarian, fallopian or peritoneal cancer age <70 as per March 6 2013 reference committee meeting
26/03/2014 Referral guidelines template discussed at March 5 2014 reference committee meeting, currently in the process of being reviewed and reformatted.
Review of these guidelines taking place in conjunction with this process and will be discussed again at October 23 2014 reference committee meeting.
12/08/2016

Referral guidelines superseded to ID 1953 (Referral Guidelines for Endometrial Cancer Risk Assessment) and ID 1905 (Referral Guidelines for Ovarian Cancer Risk Assessment).
31/05/2017 Transferred to new eviQ website. Version number changed to V.3.

The information contained in this document is based on the highest level of available evidence and consensus of the eviQ reference committee regarding their views of currently accepted approaches to care or treatment. Any clinician seeking to apply or consult this document is expected to use independent clinical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use is subject to eviQ’s disclaimer available at www.eviQ.org.au

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First approved:
Last reviewed:
Review due:

The currency of this information is guaranteed only up until the date of printing, for any updates please check:

https://www.eviq.org.au/p/1134

17 Feb 2019