All of the people who fall into the categories below warrant a referral to a family cancer clinic for assessment.
| Ovarian cancer |
| UNTESTED adult blood relative of a person with an identified mutation in an ovarian cancer predisposition gene (e.g. BRCA1, BRCA2 gene, MLH1, MSH2, MSH6, PMS2, STK11) |
| Tumour pathology |
| Characteristics that warrant referral irrespective of other factors |
| Invasive grade 2/3 non-mucinous, epithelial ovarian, fallopian tube or primary peritoneal adenocarcinoma (regardless of age) |
| Certain rare ovarian tumours (e.g. ovarian sex cord tumour with annular tubules (SCTAT), Sertoli-Leydig cell tumour, small cell ovarian carcinoma hypercalcaemic type, ovarian fibroma, ovarian leiomyoma) |
| For those with a personal history of cancer |
| Individual characteristics that warrant referral irrespective of other factors |
| Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer where there is also a personal history of breast cancer (regardless of grade and age) |
| Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer where there is Jewish ancestry (regardless of grade and age) |
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Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer (regardless of grade and age) where there is one or more close relative* with:
- ovarian cancer
- breast cancer
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Invasive epithelial ovarian cancer (regardless of age, grade and histological type) where there is one or more close relative* with:
- colorectal cancer under the age of 50 years
- endometrial cancer under the age of 50 years
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| Personal history of invasive epithelial ovarian cancer (regardless of age, grade and histological type) and a second Lynch syndrome-associated cancer |
| Personal history of invasive epithelial ovarian cancer AND a family history of 1 or more 1st or 2nd degree relatives with colorectal or endometrial cancer, with at least one of the cancers diagnosed under the age of 50 years |
| Personal history of invasive epithelial ovarian cancer AND a family history of 2 or more 1st or 2nd degree relatives with a Lynch syndrome-associated cancer regardless of the age the cancers were diagnosed |
| For those with a family history of cancer |
| Characteristics sufficient to warrant referral irrespective of other factors |
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Close relative* with invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer diagnosed at any age where there is one or more additional close relative* with:
- epithelial ovarian cancer
- breast cancer
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Close relative* with invasive epithelial ovarian cancer (regardless of age, grade and histological type) where there is one or more close relative* with:
- colorectal cancer under the age of 50 years
- endometrial cancer under the age of 50 years
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| Family history of 3 or more 1st or 2nd degree relatives with a Lynch syndrome-associated cancer, regardless of the age the cancers were diagnosed |
*close relative = 1st or 2nd degree
Lynch syndrome-associated cancer includes adenocarcinoma of the colorectum, endometrium, small intestine, stomach, ovary, or pancreas, transitional cell carcinoma of the ureter or renal pelvis, cholangiocarcinoma, brain tumour, sebaceous gland tumours, keratoacanthoma.