All of the people who fall into the categories below warrant a referral to a family cancer clinic for assessment.
Ovarian cancer |
UNTESTED adult blood relative of a person with an identified mutation in an ovarian cancer predisposition gene (e.g. BRCA1, BRCA2 gene, MLH1, MSH2, MSH6, PMS2, STK11) |
Tumour pathology |
Characteristics that warrant referral irrespective of other factors |
Invasive grade 2/3 non-mucinous, epithelial ovarian, fallopian tube or primary peritoneal adenocarcinoma (regardless of age) |
Certain rare ovarian tumours (e.g. ovarian sex cord tumour with annular tubules (SCTAT), Sertoli-Leydig cell tumour, small cell ovarian carcinoma hypercalcaemic type, ovarian fibroma, ovarian leiomyoma) |
For those with a personal history of cancer |
Individual characteristics that warrant referral irrespective of other factors |
Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer where there is also a personal history of breast cancer (regardless of grade and age) |
Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer where there is Jewish ancestry (regardless of grade and age) |
Invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer (regardless of grade and age) where there is one or more close relative* with:
- ovarian cancer
- breast cancer
|
Invasive epithelial ovarian cancer (regardless of age, grade and histological type) where there is one or more close relative* with:
- colorectal cancer under the age of 50 years
- endometrial cancer under the age of 50 years
|
Personal history of invasive epithelial ovarian cancer (regardless of age, grade and histological type) and a second Lynch syndrome-associated cancer |
Personal history of invasive epithelial ovarian cancer AND a family history of 1 or more 1st or 2nd degree relatives with colorectal or endometrial cancer, with at least one of the cancers diagnosed under the age of 50 years |
Personal history of invasive epithelial ovarian cancer AND a family history of 2 or more 1st or 2nd degree relatives with a Lynch syndrome-associated cancer regardless of the age the cancers were diagnosed |
For those with a family history of cancer |
Characteristics sufficient to warrant referral irrespective of other factors |
Close relative* with invasive non-mucinous epithelial ovarian, fallopian or primary peritoneal cancer diagnosed at any age where there is one or more additional close relative* with:
- epithelial ovarian cancer
- breast cancer
|
Close relative* with invasive epithelial ovarian cancer (regardless of age, grade and histological type) where there is one or more close relative* with:
- colorectal cancer under the age of 50 years
- endometrial cancer under the age of 50 years
|
Family history of 3 or more 1st or 2nd degree relatives with a Lynch syndrome-associated cancer, regardless of the age the cancers were diagnosed |
*close relative = 1st or 2nd degree
Lynch syndrome-associated cancer includes adenocarcinoma of the colorectum, endometrium, small intestine, stomach, ovary, or pancreas, transitional cell carcinoma of the ureter or renal pelvis, cholangiocarcinoma, brain tumour, sebaceous gland tumours, keratoacanthoma.