Familial juvenile polyposis syndrome (JPS) predisposition can be due to a germline mutation in the SMAD4 or BMPR1A gene. It is an autosomal dominant condition. Likely to have genetic heterogeneity.
Juvenile polyposis syndrome (JPS) is a predisposition to multiple hamartomatous gastrointestinal polyps, often before the age of 20.
This risk management guideline has been developed for individuals who have NOT been diagnosed with a relevant cancer/tumour. The care of affected individuals should be individualised based on their clinical situation, and the monitoring they need as part of their treatment and post-treatment follow up.