In the calculator below, glomerular filtration rate (GFR) is estimated using serum creatinine and calculated according to the Cockcroft-Gault equation. 1 Other methods used to estimate the GFR may be reported and include the Modification of Diet in Renal Disease (MDRD) study equation and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, with these used more as screening tool for kidney disease. The latter is more widely reported automatically by clinical laboratories every time a creatinine is measured. 2
Although the MDRD and CKD-EPI equations have been shown to be more accurate, the majority of recommendations for dose adjustments in renal impairment were made based on the assumption that the GFR was estimated using the Cockcroft-Gault equation. This formula is usually applied to calculate creatinine clearance (CrCl) prior to dosing.2
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15 Jul 2020