To see all protocols that comply with the WHO Essential Medicine List 
  • This clinical procedure outlines the management of an extravasation with the following vesicant drugs vinblastine, vincristine, vindesine, vinflunine or vinorelbine. Only health care professionals who have expertise and the knowledge of cytotoxic drugs and who have attained competency as per institutional guidelines in extravasation management should perform this procedure.
  • There have been some clinical reports of positive outcomes with using hyaluronidase as an antidote for paclitaxel extravasations. If hyaluronidase is administered for a paclitaxel extravasation no compress is recommended.
  • Extravasation of a vesicant is a medical emergency; early detection and prompt appropriate action is required to prevent necrosis and functional loss of the tissue or limb involved.

This procedure should be read in conjunction with the Extravasation management document and the Immediate management of an extravasation flow chart.

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16 Feb 2019