The subjective sensations of difficulty swallowing or breathing without objective evidence of laryngopharyngeal dysfunction or respiratory distress, related to oxaliplatin treatment.
An acute sensory neurological toxicity, without evidence of cyanosis or hypoxia, laryngospasm or bronchospasm. Often occurs on exposure to cold and changes in temperature.
Reactions of any grade reported to occur in 38.2% of patients, with grade 3 to 4 reactions in 1.5% of patients receiving oxaliplatin treatment. Must be differentiated from a platinum hypersensitivity reaction which can occur in up to 20% of patients treated with oxaliplatin and requires early and more intensive intervention.
During or within 48 hours following oxaliplatin treatment.