Fluid retention is a side effect associated with docetaxel, and appears to be caused by capillary leak.
Fluid retention associated with docetaxel presents most frequently as peripheral oedema and weight gain, and less frequently as pleural effusion and/or ascites. It is thought to be caused by increased permeability of the capillaries, resulting in leakage of fluid into the surrounding tissue.
The onset and severity of fluid retention is related to cumulative dose. The median cumulative dose to onset for treatment with 75 mg/m2 is 524 mg/m2, and for treatment with 100 mg/m2 is 509 mg/m2 (without premedication) and 797 mg/m2 (with premedication). Fluid retention is slowly reversible after treatment with docetaxel has ceased.
The main risk factor for developing fluid retention associated with docetaxel is cumulative dose.