Grade 1: haemoglobin (Hgb) < LLN - 10 g/dL; < LLN - 6.2 mmol/L; < LLN - 100 g/L

Grade 2: haemoglobin (Hgb) < 10.0 - 8.0 g/dL; < 6.2 - 4.9 mmol/L; < 100 - 80 g/L

Grade 3: haemoglobin (Hgb) < 8.0 g/dL; < 4.9 mmol/L; < 80 g/L; transfusion indicated

Grade 4: life threatening consequences; urgent intervention indicated

Grade 5: death

Adapted from Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 Published: May 28, 2009 (v4.03: June 14, 2010)