To see all protocols that comply with the WHO Essential Medicine List 

Grade 1: occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema

Grade 2: persistent symptoms with regular use of laxatives or enemas; limiting instrumental activities of daily living

Grade 3: obstipation with manual evacuation indicated; limiting self care activities of daily living

Grade 4: life-threatening consequences; urgent intervention indicated

Reference: Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 Published: November 27, 2017