Grade 1: increase of creatine phosphokinase of greater than ULN to 2.5 x ULN

Grade 2: increase of creatine phosphokinase of greater than 2.5 x ULN to 5 x ULN

Grade 3: increase of creatine phosphokinase of greater than 5 x ULN to 10 x ULN

Grade 4: increase of creatine phosphokinase of greater than 10 x ULN

Reference: Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 Published: Novermber 27, 2017