Grade 1: asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
Grade 2: moderate; minimal, local or noninvasive intervention indicated; limiting age appropriate instrumental activities of daily living
Grade 3: severe or medically significant but not immediately life threatening; hospitalisation or prolongation of existing hospitalisation indicated; disabling; limiting self care activities of daily living
Grade 4: life threatening consequences; urgent intervention indicated
Adapted from Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 Published: November 27, 2017
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