To see all protocols that comply with the WHO Essential Medicine List 
 Methotrexate interactions:

Avoid administering the following drugs in combination with high dose methotrexate: ciprofloxacin, NSAIDs, probenecid, Proton Pump Inhibitors (PPIs) (e.g. esomeprazole, omeprazole, pantoprazole), sulphonamides (e.g. sulfamethoxazole (in Bactrim®, Septrin®)), penicillins (e.g. piperacillin (in Tazocin®)) and trimethoprim. Severe mucositis may occur if administered together.

This protocol is based on limited evidence; please refer to the evidence section of this protocol for more information.

This protocol has been created specifically as an induction protocol prior to conditioning with ID 3593 - Autologous conditioning protocol primary CNS lymphoma TBC - part 2 . Please note that it differs from other R-MPV protocols on the site in its intention to treat. 

The information contained in this protocol is based on the highest level of available evidence and consensus of the eviQ reference committee regarding their views of currently accepted approaches to treatment. Any clinician (medical oncologist, haematologist, radiation oncologist, medical physicist, radiation therapist, pharmacist or nurse) seeking to apply or consult this protocol is expected to use independent clinical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. Use is subject to eviQ’s disclaimer available at

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31 May 2020