Cytokine release syndrome (CRS) and neurological toxicity with cellular therapy:

Cytokine release syndrome (CRS) and neurological toxicity, including fatal or life-threatening reactions, have occurred in patients receiving this treatment.

Confirm tocilizumab is available prior to commencing treatment in the event of developing cytokine release syndrome (CRS).

Refer to the Medical Services Advisory Centre (MSAC) for guidance on patients to consider for cellular therapy. Link to MSAC website.

Patients with leukaemia should be considered for inclusion into clinical trials. Link to ALLG website and ANZCTR website.

This protocol is based on limited evidence; refer to the evidence section of this protocol for more information.

The information contained in this protocol is based on the highest level of available evidence and consensus of the eviQ reference committee regarding their views of currently accepted approaches to treatment. Any clinician (medical oncologist, haematologist, radiation oncologist, medical physicist, radiation therapist, pharmacist or nurse) seeking to apply or consult this protocol is expected to use independent clinical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. While eviQ endeavours to link to reliable sources that provide accurate information, eviQ and the Cancer Institute NSW do not endorse or accept responsibility for the accuracy, currency, reliability or correctness of the content of linked external information sources. Use is subject to eviQ’s disclaimer available at www.eviQ.org.au

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The currency of this information is guaranteed only up until the date of printing, for any updates please check:

https://www.eviq.org.au/p/3832

04 Nov 2024