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Welcome to the cancer of unknown primary (CUP) homepage of eviQ

The cancer of unknown primary (CUP), also referred to as occult primary malignancy (OPM) or tumour of unknown origin (TUO), is a term used to classify metastatic cancer which has an unidentifiable site of origin at the time of diagnosis.

The treatment for CUP is different for every person. Treatment options include chemotherapy, radiotherapy, hormone therapy, surgery and targeted therapies.1,2 Chemotherapy treatments are based upon the histological type of cancer.3


  1. Cancer Council Australia 2017, viewed 28 August 2017,
  2. Australian Government Cancer Australia 2017, viewed 28 August 2017,
  3. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) - Occult primary - V.2.2017
    NB: CUP is referred to as 'Occult primary' on NCCN

For further information on cancer of unknown primary please visit the following websites: