This protocol is no longer in use in clinical practice as there is no evidence demonstrating equivalent efficacy for day 8 dosing of carboplatin vs the day 1 schedule.
Treatment Schedule Summary
||1 and 8
*If estimated GFR is greater than 125 mL/min (i.e. 5 AUC dose greater than 750 mg), obtaining direct measurement rather than an estimated renal function and/or dose capping is strongly recommended.
**In this protocol, the carboplatin is given on day 8, not on day 1 as in the original study, to ensure that day 1 of the following cycle need not be delayed or omitted due to haematological toxicities.
Frequency: 21 days
Cycles: Continuous until disease progression or unacceptable toxicity, up to 6 cycles