There was one treatment related death and grade 3/4 adverse events affecting haematological, skin, gastrointestinal and fatigue occurred in the phase II study of radiation therapy and weekly cisplatin.r
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Mak et alr demonstrated greater grade 3 acute skin toxicity in patients receiving weekly cisplatin compared with those receiving 3- 4 weekly 5FU based treatments (62.5% vs. 32.0%). However, there was an increased rate of gastrointestinal toxicity in the 5FU group (46.1% vs 13.3%). There were no treatment related deaths.
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