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 Warning: QT prolongation, torsades de pointes and sudden death:

Vandetanib can prolong the QT interval and may cause fatal or life-threatening ventricular arrhythmias (including torsades de pointes) or sudden death.  Vandetanib should not be commenced in patients with QTc >480 ms, congenital long QT syndrome or a history of arrhythmias (unless all contributing risk factors have been corrected). ECG and electrolytes should be monitored at baseline and regularly throughout treatment. Drugs known to prolong the QT interval should be avoided. Caution is advised if concomitant CYP3A4 inhibitors are used, as vandetanib is metabolised by CYP3A4. Vandetanib has a long half life - the risk of QT prolongation and arrhythmia may remain for a period of weeks after cessation of therapy.

Check for clinical trials in this patient group. Link to Australian Clinical Trials website

The anticancer drug(s) in this protocol may have been included in the ADDIKD guideline. Dose recommendations in kidney dysfunction have yet to be updated to align with the ADDIKD guideline. Recommendations will be updated once the individual protocol has been evaluated by the reference committee. For further information refer to the ADDIKD guideline. To assist with calculations, use the eviQ Estimated Glomerular Filtration Rate (eGFR) calculator.

The information contained in this protocol is based on the highest level of available evidence and consensus of the eviQ reference committee regarding their views of currently accepted approaches to treatment. Any clinician (medical oncologist, haematologist, radiation oncologist, medical physicist, radiation therapist, pharmacist or nurse) seeking to apply or consult this protocol is expected to use independent clinical judgement in the context of individual clinical circumstances to determine any patient's care or treatment. While eviQ endeavours to link to reliable sources that provide accurate information, eviQ and the Cancer Institute NSW do not endorse or accept responsibility for the accuracy, currency, reliability or correctness of the content of linked external information sources. Use is subject to eviQ’s disclaimer available at www.eviQ.org.au

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First approved:
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Superseded:
Discontinued:

The currency of this information is guaranteed only up until the date of printing, for any updates please check:

https://www.eviq.org.au/p/1727

29 Mar 2024