Efficacy
At the time of analysis and median follow up of 27 months, the hazard ratio for overall survival with use of adjuvant temozolomide was 0.65 (99.125% CI, 0.45 - 0.93). Overall survival at 5 years was 55.9% (95% CI, 47.2 - 63.8) with, and 44.1% (36.3 - 51.6) without adjuvant temozolomide.r
The data do not necessarily imply that concurrent temozolomide has no beneficial effect, but at the time of the interim analysis the survival values did not cross the predefined boundaries.
The survival curves for adjuvant versus no adjuvant temozolomide diverged further with increasing length of follow-up, which suggests that with time overall survival could improve further. The role for concurrent temozolomide therefore remains to be clarified.
The study protocol was amended in 2011 to incorporate analysis of mutations in IDH1 and IDH2 to investigate their predictive value for temozolomide efficacy, for which the analyses are pending. MGMT methylation analysis with respect to treatment efficacy is ongoing and the results are not currently available

© Lancet 2017
(A) Overall survival, and B) Progression-free survival, according to treatment group

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