To see all protocols that comply with the WHO Essential Medicine List 

 The following is a guide for methods of management at home:

Drugs that are vesicants and require require hyaluronidase and warm compress - vinblastine, vincristine, vindesine, vinflunine, vinorelbine.

Drugs that are vesicants and require DMSO 99% solution and cold compress - amsacrine, dactinomycin (actinomycin D), daunorubicin, doxorubicin, epirubicin, idarubicin, mitomycin.

Drugs that are vesicants and require cold compress - cisplatin ( > 0.5 mg/mL).

Drugs that are irritants with vesicant properties and require cold compress - bendamustine, docetaxel, doxorubicin liposomal, melphalan, mitozantrone, paclitaxel*, nab-paclitaxel.

Drugs that are irritants with vesicant properties and do not require any compress - oxaliplatin.

* There have been some clinical reports of positive outcomes with using hyaluronidase as an antidote for paclitaxel extravasation. If hyaluronidase is administered, no compress is recommended.

This form is adapted from the "Patient Information Sheet on Extravasation" by the Chemotherapy Nurses Group at NHS Sussex Cancer Network.

This document is a guide only and cannot cover every possible situation. The health professionals caring for you should always consider your individual situation when making decisions about your care. Contact your cancer clinic staff or doctor if you have any questions or concerns about your treatment, or you are having problems coping with side effects. Use of this document is subject to eviQ’s disclaimer available at

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26 May 2020