Actinic keratoses (AKs) are common skin lesions that usually occur as a result of chronic sun exposure.The immunosuppressant effect of most chemotherapy regimens can cause pre-existing AKs to become more inflamed and scaly. They mainly occur in older men with fair skin.
AKs are commonly scaly, red patches (that can be either flat or raised) on areas such as the scalp, face, side of neck, forearms and hands. Actinic cheilitis is a variant of AK that involves the lip.
Onset of actinic keratoses flare is within days to weeks of commencing chemotherapy.