Radiation recall is an erythematous or inflammatory skin reaction (resembles severe sunburn, and can include vesiculation, desquamation, and ulceration) that can occur at the site of previous radiation when certain chemotherapy drugs are given.
Onset of radiation recall can be more rapid following intravenous (IV) administration of chemotherapy (several minutes to two weeks) than with orally administered agents (where the average onset is days to weeks). Duration is similarly different - IV related reactions usually resolve within about two weeks, while reactions following PO drug administration can last for several months.
The drugs that are associated with radiation recall include:
- doxorubicin (free and liposomal)