To see all protocols that comply with the WHO Essential Medicine List 

This document is a quick and concise evidence-based summary to provide additional information, instruction, or guidance to complement a treatment protocol or clinical resource document. 

International Germ Cell Cancer Collaborative Group (IGCCCG): International germ cell consensus classification: a prognostic factor-based staging system for metastatic germ cell tumours (GCT).

For predict outcome for individual patients refer to: IGCCCG Individual 3-year progression-free survival prediction of first line metastatic non-seminoma patients.

Risk classificationr Non seminoma Seminoma
Good prognosis

Testicular or retroperitoneal primary tumour
and
No non-pulmonary visceral metastases
and
Post-orchiectomy markers - all of:

  • AFP less than 1000 microgram/L
  • ßhCG less than 5000 International units/L
  • LDH less than 2.5 x upper limit of normalr

Any primary site
and
No non-pulmonary visceral metastases
and
Normal AFP, any ßhCG, any LDH

56% of non-seminoma
5-year PFS 90%
5-year OS 96%

90% of seminoma
5-year PFS 89%
5-year OS 95%r
Intermediate prognosis

Testicular or retroperitoneal primary tumour
and
No non-pulmonary visceral metastases
and
Post-orchiectomy markers - any of:

  • AFP 1000 to 10 000 microgram/L
  • ßhCG 5000 to 50 000 International units/L
  • LDH 1.5 to 10 x upper limit of normal

Any primary site
and
Non-pulmonary visceral metastases
and
Normal AFP, any ßhCG, any LDH

28% of non-seminoma
5-year PFS 78%
5-year OS 89%

10% of seminoma
5-year PFS 79%
5-year OS 72%
r

Poor prognosis

Mediastinal primary tumour
or
Non-pulmonary visceral metastases
or
Post-orchiectomy markers -

any of:

  • AFP greater than 10 000 microgram/L
  • ßhCG greater than 50 000 International units/L
  • LDH greater than 10 x upper limit of normal
No patients classified as poor prognosis

16% of non-seminoma
5-year PFS 54%
5-year OS 67%

 
AFP: alpha-fetoprotein
ßhCG: beta human chorionic gonadotrophin
LDH: lactate dehydrogenase

Send feedback for this page


Last reviewed:
Review due:

The currency of this information is guaranteed only up until the date of printing, for any updates please check:

https://www.eviq.org.au/p/196

19 Mar 2024