Adult family members of someone with a faulty PALB2 gene can have genetic testing to check who has the faulty gene and who does not. Their doctor can refer them to a genetic service to find out more about their chance of developing cancer and what genetic testing involves.
If a person does have the faulty PALB2 gene:
- they can pass it on to their children
- each child has a 50% (1 in 2) chance of being born with it. Pregnancy planning options are available to people who want to prevent the faulty gene from being passed on.
When two people with the faulty PALB2 gene have children together, each child has a 25% (1 in 4) chance of being born with two faulty PALB2 genes. People with two faulty PALB2 genes have a condition called Fanconi anaemia (complementation group N). Fanconi anaemia may affect many parts of the body including bone marrow, skin, skeletal system, physical growth and development. People with Fanconi anaemia also have an increased chance of developing cancer from childhood.
If a person does not have the faulty PALB2 gene:
- they have the same chance of developing cancer as the general population (unless there are other factors that increase this risk)
- they cannot pass it on to their children.
People who decide not to have genetic testing should still get advice about managing their chance of developing cancer. |