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This fact sheet contains general information. Each person should be referred to a genetic service for further information and advice about what a diagnosis of CMMRD means for them.

Key Points

  • Both men and women with one faulty mismatch repair gene (MLH1, PMS2, MSH2 or MSH6) have Lynch syndrome (also known as HNPCC) and have an increased chance of developing cancer in adulthood – see ‘Facts for people and families with a faulty MLH1 gene - eviq.org.au/p/3451; Facts for people and families with a faulty MSH2 gene - eviq.org.au/p/3452; Facts for people and families with a faulty MSH6 gene - eviq.org.au/p/3453; Facts for people and families with a faulty PMS2 gene - eviq.org.au/p/3454.
  • Both men and women with a faulty mismatch repair gene can pass it on to their children.
  • Children who inherit two of the same faulty mismatch repair genes (one from their mother and one from their father) have CMMRD and have an increased chance of developing cancer from childhood.
  • Family members (including children) can be referred to a genetic service where experts can provide information, advice and support about their chance of developing cancer and the option of genetic testing.

This cancer genetics fact sheet is a guide only and cannot cover every possible situation. The information provided is not intended to replace discussion with a health professional, and should not be interpreted as medical advice. While eviQ endeavours to link to reliable sources that provide accurate information, eviQ and the Cancer Institute NSW do not endorse or accept responsibility for the accuracy, currency, reliability or correctness of the content of linked external information sources. Use of this document is subject to eviQ's disclaimer available at  www.eviQ.org.au  

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https://www.eviq.org.au/p/4057

05 Jul 2022