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Hand foot syndrome (Palmar-plantar erythrodysaesthesia syndrome)

Grade 1: minimal skin changes or dermatitis (e.g., erythema, oedema, or hyperkeratosis) without pain

Grade 2: skin changes (e.g., peeling, blisters, bleeding, fissures, oedema, or hyperkeratosis) with pain; limiting instrumental activities of daily living

Grade 3: severe skin changes (e.g., peeling, blisters, bleeding, fissures, oedema, or hyperkeratosis) with pain; limiting self care activities of daily living

Reference: Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 Published: November 27, 2017