Grade 1: AST/ALT >ULN - 3.0 x ULN if baseline was normal; 1.5 - 3.0 x baseline if baseline was abnormal;
bilirubin >ULN - 1.5 x ULN if baseline was normal; >1.0 - 1.5 x baseline if baseline was abnormal

Grade 2: AST/ALT >3.0 - 5.0 x ULN if baseline was normal; >3.0 - 5.0 x baseline if baseline was abnormal;
bilirubin >1.5 - 3.0 x ULN if baseline was normal; >1.5 - 3.0 x baseline if baseline was abnormal

Grade 3: AST/ALT >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal;
bilirubin >3.0 - 10.0 x ULN if baseline was normal; >3.0 - 10.0 x baseline if baseline was abnormal

Grade 4: AST/ALT >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal;
bilirubin >10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal

Reference: Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 Published: November 27, 2017