FBC, EUC, eGFR, LFTs, calcium, magnesium, serum cortisol, TFTs and BSL at baseline.
Repeat FBC, EUC, eGFR, LFTs and BSL prior to each cycle and serum cortisol and TFTs alternate cycles. Calcium and magnesium as clinically indicated. Check lipase and amylase if symptomatic of pancreatitis.
Recalculation of carboplatin doses at each cycle is unnecessary, except when baseline kidney function (e.g., eGFR) alters by greater than 20% or when there is a change in the clinical status of the patient.
In the absence of suspicion of immune related adverse events less frequent monitoring may be applicable, according to institutional guidelines. Evidence for the frequency of routine blood testing with immunotherapies varies within published studies and guidelines.